Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report
Identifieur interne : 002C24 ( Main/Exploration ); précédent : 002C23; suivant : 002C25Complications in the treatment of oropharyngeal carcinoma in patients with systemic sclerosis: A case report
Auteurs : Ales O Ek [République tchèque] ; Ales Hahn [République tchèque] ; Miloslav Ambruš [République tchèque] ; Marie Valešová [République tchèque]Source :
- Oncology Letters [ 1792-1074 ] ; 2014.
Abstract
Systemic sclerosis is a chronic, progressive disease with an extremely poor prognosis. The incidence of malignant tumors in patients with systemic sclerosis is increased when compared with that of the general population. In certain malignancies, systemic sclerosis presents as a paraneoplastic process. The symptoms of sclerosis in the organs of the head and neck often overlap with symptoms of malignant diseases, which may increase the difficulty of a differential diagnosis. Additionally, the presence of sclerosis may complicate standard examination procedures, due to poor access to the oral cavity and oropharynx. When considering treatment options, it is important to evaluate the surgical and oncological risks to soft tissues of the head and neck with regard to both diseases, as well as the relatively poor prognosis for systemic sclerosis and oropharyngeal cancer. The low incidence of patients with systemic sclerosis and oropharyngeal carcinoma together presents a clear case for a casuistic approach. Based upon our own experience, we can attest to the difficulty of treating such patients. However, we have no evidence to indicate that these patients have reduced tolerance to surgical treatments. The current study presents the case of a 47-year-old female with systemic sclerosis, who was diagnosed with oropharyngeal carcinoma. The patient initially tolerated radiotherapy treatment well, however post-radiotherapy complications occurred. Despite many enigmatic indications to the contrary, it appears that the complications in this instance may be due to late toxicity from radiotherapy.
Url:
DOI: 10.3892/ol.2014.2627
PubMed: 25435929
PubMed Central: 4246633
Affiliations:
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systemic sclerosis: A case report</title><author><name sortKey=" O Ek, Ales" sort=" O Ek, Ales" uniqKey=" O Ek A" first="Ales" last=" O Ek">Ales O Ek</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-09-01-0025">ENT Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>ENT Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10</wicri:regionArea><wicri:noRegion>100 34 Prague 10</wicri:noRegion></affiliation></author><author><name sortKey="Hahn, Ales" sort="Hahn, Ales" uniqKey="Hahn A" first="Ales" last="Hahn">Ales Hahn</name><affiliation wicri:level="1"><nlm:aff id="af1-ol-09-01-0025">ENT Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>ENT Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10</wicri:regionArea><wicri:noRegion>100 34 Prague 10</wicri:noRegion></affiliation></author><author><name sortKey="Ambrus, Miloslav" sort="Ambrus, Miloslav" uniqKey="Ambrus M" first="Miloslav" last="Ambruš">Miloslav Ambruš</name><affiliation wicri:level="1"><nlm:aff id="af2-ol-09-01-0025">Radiotherapy and Oncology Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>Radiotherapy and Oncology Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10</wicri:regionArea><wicri:noRegion>100 34 Prague 10</wicri:noRegion></affiliation></author><author><name sortKey="Valesova, Marie" sort="Valesova, Marie" uniqKey="Valesova M" first="Marie" last="Valešová">Marie Valešová</name><affiliation wicri:level="1"><nlm:aff id="af3-ol-09-01-0025">First Internal Medicine Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10, Czech Republic</nlm:aff><country xml:lang="fr">République tchèque</country><wicri:regionArea>First Internal Medicine Clinic, Charles University Third Medical School and Královské Vinohrady Teaching Hospital, 100 34 Prague 10</wicri:regionArea><wicri:noRegion>100 34 Prague 10</wicri:noRegion></affiliation></author></analytic><series><title level="j">Oncology Letters</title><idno type="ISSN">1792-1074</idno><idno type="eISSN">1792-1082</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Systemic sclerosis is a chronic, progressive disease with an extremely poor prognosis. The incidence of malignant tumors in patients with systemic sclerosis is increased when compared with that of the general population. In certain malignancies, systemic sclerosis presents as a paraneoplastic process. The symptoms of sclerosis in the organs of the head and neck often overlap with symptoms of malignant diseases, which may increase the difficulty of a differential diagnosis. Additionally, the presence of sclerosis may complicate standard examination procedures, due to poor access to the oral cavity and oropharynx. When considering treatment options, it is important to evaluate the surgical and oncological risks to soft tissues of the head and neck with regard to both diseases, as well as the relatively poor prognosis for systemic sclerosis and oropharyngeal cancer. The low incidence of patients with systemic sclerosis and oropharyngeal carcinoma together presents a clear case for a casuistic approach. Based upon our own experience, we can attest to the difficulty of treating such patients. However, we have no evidence to indicate that these patients have reduced tolerance to surgical treatments. The current study presents the case of a 47-year-old female with systemic sclerosis, who was diagnosed with oropharyngeal carcinoma. The patient initially tolerated radiotherapy treatment well, however post-radiotherapy complications occurred. Despite many enigmatic indications to the contrary, it appears that the complications in this instance may be due to late toxicity from radiotherapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kuo, Cf" uniqKey="Kuo C">CF Kuo</name></author><author><name sortKey="Luo, Sf" uniqKey="Luo S">SF Luo</name></author><author><name sortKey="Yu, Kh" uniqKey="Yu K">KH Yu</name></author><author><name sortKey="Chou, Ij" uniqKey="Chou I">IJ Chou</name></author><author><name sortKey="Tseng, Wy" uniqKey="Tseng W">WY Tseng</name></author><author><name sortKey="Chang, Hc" uniqKey="Chang H">HC Chang</name></author><author><name sortKey="Fang, Yf" uniqKey="Fang Y">YF Fang</name></author><author><name sortKey="Chiou, Mj" uniqKey="Chiou M">MJ Chiou</name></author><author><name sortKey="See, Lc" uniqKey="See L">LC See</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kang, Ky" uniqKey="Kang K">KY 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deGuzman</name></author><author><name sortKey="Ekstrand, Kf" uniqKey="Ekstrand K">KF Ekstrand</name></author><author><name sortKey="Ellis, Tl" uniqKey="Ellis T">TL Ellis</name></author><author><name sortKey="Lovato, Jf" uniqKey="Lovato J">JF Lovato</name></author><author><name sortKey="Mcmullen, K" uniqKey="Mcmullen K">K McMullen</name></author><author><name sortKey="Munley, Mj" uniqKey="Munley M">MJ Munley</name></author><author><name sortKey="Shaw, Eg" uniqKey="Shaw E">EG Shaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, A" uniqKey="Lin A">A Lin</name></author><author><name sortKey="Abu Isa, E" uniqKey="Abu Isa E">E Abu-Isa</name></author><author><name sortKey="Griffith, Ka" uniqKey="Griffith K">KA Griffith</name></author><author><name sortKey="Ben Josef, E" uniqKey="Ben Josef E">E Ben-Josef</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République tchèque</li></country></list><tree><country name="République tchèque"><noRegion><name sortKey=" O Ek, Ales" sort=" O Ek, Ales" uniqKey=" O Ek A" first="Ales" last=" O Ek">Ales O Ek</name></noRegion><name sortKey="Ambrus, Miloslav" sort="Ambrus, Miloslav" uniqKey="Ambrus M" first="Miloslav" last="Ambruš">Miloslav Ambruš</name><name sortKey="Hahn, Ales" sort="Hahn, Ales" uniqKey="Hahn A" first="Ales" last="Hahn">Ales Hahn</name><name sortKey="Valesova, Marie" sort="Valesova, Marie" uniqKey="Valesova M" first="Marie" last="Valešová">Marie Valešová</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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